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3-Isobutyl-1-methylxanthine, 5 x 5 g, Each of 5

4,712.51

Details

Specifications Synonym: 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMXCAS Number: 28822-58-4Empirical Formula (Hill Notation): C10H14N4O2Molecular Weight: 222.24Beilstein Registry Number: 247859EC Number: 249-259-3MDL Number: MFCD00005584PubChem Substance ID: 242776806Packaging 1, 5 g in poly bottle; 250 mg in poly tube; 100 mg in poly bottleBiochem/physiol Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 µM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1Assay: =99% (HPLC)Form: powderColor: white to off-whiteMP: 200-201 °C(lit.)Solubility: DMSO: soluble1 M (with gentle warming), ethanol: soluble10 mg/mLStorage Temp.: -20°CGene Information: human ... PRKAR1A, PRKAR1AP, PRKAR1B, PRKAR2A, PRKAR2B; rat ... Adora1, Adora2a

Additional Information

SKU 5154079
UOM Each of 5
UNSPSC 12352100
Manufacturer Part Number I5879-5X5G
CAS Number 28822-58-4
Is Hazardous Yes
HS Code 2933599000