Adiporon,Chemical. Cas: 924416-43-3, Each

Details:

Adiporon, adipogen life sciences. Chemical. Cas: 924416-43-3. Formula: c27h28n2o3. Mw: 428.5. Orally-active adiponectin receptor (adipor) agonist. Binds to adipor1 and adipor2 at low m concentration. Activates 5'-adenosine monophosphate-activated protein kinase (ampk) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by adipor-dependent mechanisms. Rescued the shortened lifespan of db/db mice (adipors ko) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as tnf-alpha, il-6 and ccl-2 in wat of wt mice but not db/db mice.