Borrelidin,Chemical. Cas: 7184-60-3, Each

Details:

Borrelidin, adipogen life sciences. Chemical. Cas: 7184-60-3. Formula: c28h43no6. Mw: 489.6. Isolated from streptomyces sp. Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-trna synthetase (thrrs) inhibitor. Antiangiogenic (ic50 = 0.8 Nm) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In huvecs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of b16-bl6 melanoma cells. Cyclin-dependent kinase (cdk) inhibitor. Antiviral. Potent antimalarial agent (ic50 = 0.97 Nm). Inhibitor of potato scab disease.