Cyclopamine,Chemical. Cas: 4449-51-8, Each

Details:

Cyclopamine, adipogen life sciences. Chemical. Cas: 4449-51-8. Formula: c27h41no2. Mw: 411.6. Isolated from veratrum californicum. Cell permeable steroidal alkaloid. Specific sonic hedgehog (shh) signaling pathway inhibitor. Directly interacts/inhibits smo (smoothened). Teratogenic and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against shh-dependent tumors. Blocks abnormal cell growth associated with oncogenic mutations of ptch and smo in fibroblasts. Arrests cell cycle at g0/g1. Apoptosis inducer.