Cyclosporin A,Chemical. Cas: 59865-13-3, Each

Details:

Cyclosporin a, adipogen life sciences. Chemical. Cas: 59865-13-3. Formula: c62h111n11o12. Mw: 1202.6. Isolated from tolypocladium inflatum. Potent immunosuppressant (same as fk-506 (prod. No. Ag-cn2-0047) and rapamycin (prod. No. Ag-cn2-0025)). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2b (pp2b; calcineurin). Prevents the dephosphorylation of nuclear factor of activated t cells (nfat) transcription factor, leading to disruption of t cell activation. Suppresses proliferation of cytotoxic t cells and inhibits the production of t cell-derived mediators such as interleukin-2 (il-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.G. Atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor.