Epoxomicin,Chemical. Cas: 134381-21-8, Each

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Epoxomicin, adipogen life sciences. Chemical. Cas: 134381-21-8. Formula: c28h50n4o7. Mw: 554.7. Synthetic. Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20s proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (ctrl) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces parkinson's-like symptoms in rats. The ubiquitin-proteasome system (ups) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of ups by epoxomicin activates autophagy.