Fk-506,Chemical. Cas: 109581-93-3, Each

Details:

Fk-506, adipogen life sciences. Chemical. Cas: 109581-93-3. Formula: c44h69no12 . H2o. Mw: 804.0 . 18.0. Isolated from streptomyces fcz0311. Potent immunosuppressant (as cyclosporin a and rapamycin). Suppresses proliferation of cytotoxic t cells and inhibits the production of t cell-derived mediators such as interleukin-2 (il-2). Forms a complex with fk-506 binding protein 12 (fkbp12). Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2b (pp2b; calcineurin), leading to disruption of t cell activation. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.G. Atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2 release compound. Nf-kappab suppressor by induction of unfolded protein response (upr). Anti-cancer compound. Apoptosis inducer.