Pma, Chemical. Cas: 16561-29-8;, Each

Details:

Pma, adipogen life sciences. Chemical. Cas: 16561-29-8. Formula: c36h56o8. Mw: 616.8. Semisynthetic. Most commonly-used phorbol ester. Binds to and activates protein kinase c (pkc) at nm concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (mapks), p38 and c-jun n-terminal kinase (jnk) pathways mediated by cyclin dependent kinase (cdk) inhibitors such as p21waf1/cip1, p27kip1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible nos (inos; nos ii). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin.