Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile) Chemical. CAS: 31852-29-6, Each

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Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile), AdipoGen Life Sciences. Chemical. CAS: 31852-29-6. MW: High molecular weight (>1.5kb). Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-alpha and antiviral IFN-beta, but can also enhance the expression of pro-apoptotic proteins.