Polyinosinic-Polycytidylic Acid [Poly(I:C)] Endotoxin-Free (Sterile) Chemical. Cas: 31852-29-6, Each

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Polyinosinic-polycytidylic acid [poly(i:c)] endotoxin-free (sterile), adipogen life sciences. Chemical. Cas: 31852-29-6. Mw: high molecular weight (>1.5Kb). Toll-like receptor (tlr) 3 is an endosomal tlr that mediates immune responses against viral infections upon activation by its ligand double-stranded rna, a replication intermediate of most viruses. Tlr3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (tlr3), melanoma differentiation-associated gene 5 (mda5), and retinoic acid-inducible gene-i (rig-i), all sensors of double-stranded rna (dsrna) are potent inducers of antiviral activity. Dsrna sensor activation -e.G. By poly (i:c)- induces pro-inflammatory tnf-alpha and antiviral ifn-beta, but can also enhance the expression of pro-apoptotic proteins.