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A potent protease inhibitor.Aprotinin acts as a reversible serine protease blocking and a binding agent. It is widely employed as an inhibitor of trypsin. It is also used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones. It is involved in the purification of urokinase, trypsin, and chymotrypsin on immobilized aprotinin. Further, it is used in the quantification of kallikrein activity in mixtures of esterases and proteases. General • Aprotinin is a 58-amino acid polypeptide chain found in lung tissue• Aprotinin can suppress the systemic inflammatory response by reversibly inhibiting various esterases and proteases; it acts as a broad spectrum serine protease inhibitorApplication• Aprotinin can be used as an enzyme inhibitor in laboratory studies on chymotrypsin, kallikrein, plasmin, and others• Aprotinin is useful for the laboratory study of post-operative bleeding and wound healing
