Aromatase inhibitor used to treat ER-positive breast cancer. It suppresses estrogen synthesis and induces apoptosis in breast cancer cells, Each

Details

Anastrozole is a third generation aromatase inhibitor that suppresses synthesis of estrogen. Anastrozole exhibits anticancer chemotherapeutic activity and is clinically used to treat ER-positive breast cancer. In vitro, anastrozole inhibits proliferation of cancer cells by disrupting the mitochondrial membrane potential and inducing apoptosis. Because of its anti-estrogen properties, anastrozole may decrease bone mineral density and increase fracture risk.