Bcl-X Set Mouse, Unlabeled, Clone: 2h12, Bd, Mouse Monoclonal Antibody, Each

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Members of the bcl-2 family play a major role in regulating the response of cells to a wide variety of apoptotic signals. Some bcl-2 family members like bcl-2, block apoptosis, whereas others promote apoptosis and inhibit bcl-2 activity. Bcl-x is a bcl-2 homologue that has two isoforms, resulting from alternative splicing. Bcl-xl (long) is a 241 amino acid protein (25-29 kda) that is 47% homologous to bcl-2 on the amino acid level. Bcl-xs (short) is a 178 amino acid protein (∼ 19.5 Kda) lacking a 63 amino acid domain that is well conserved among members of the bcl-2 protein family. Bcl-xl blocks cell death, whereas bcl-xs inhibits bcl-2 and promotes cell death.