C-Myc With Control Mouse Anti-Human, Unlabeled, Clone: 9e10., Bd, Mouse Monoclonal Antibody, Each

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The myc gene family contains at least seven closely related genes, c-myc, n-myc, l-myc, p-myc, r-myc, s-myc, and b-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (cacgtg) dna binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. Dna binding of myc-max dimers results in a conformational change of the dna and transcriptional activation. C-myc migrates at 62 kda in sds-page. Clone 9e10 recognizes human c-myc. A synthetic peptide corresponding to a c-terminal epitope of the human c-myc protein (aeeqkliseedl) was used as an immunogen.