$ 480.00
Details
The 2D7 monoclonal antibody specifically binds to the 180-kDa α; L chain of LFA-1 (CD11a/CD18, α; L β; 2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. CD8a CD8b- intestinal intraepithelial T lymphocytes, which are believed to be thymus independent, do not express CD11a. LFA-1 mediates a variety of heterotypic and homotypic intracellular adhesions through interaction with ICAM-1 (CD54) and ICAM-2 (CD102), including participation in the immunological synapses between CD8 T lymphocytes and antigen-presenting cells. mAb 2D7 has been reported to block an in vitro allogeneic mixed-leukocyte reaction. The 2D7 and M17/4 (Cat. No. 553337, for the NA/LE™ format) antibodies are reported to recognize different epitopes of the CD11a molecule.
