Cd11a Rat Anti-Mouse, Unlabeled, Clone: M17/4, Bd, Rat Monoclonal Antibody, Each

Details:

The m17/4 antibody reacts with the 180 kda α; l chain of lfa-1 (cd11a/cd18, α; l β; 2 integrin), a heterodimeric surface glycoprotein expressed on almost all leukocytes. Cd8a+cd8b- intestinal intraepithelial t lymphocytes, which are believed to be thymus independent, do not express cd11a. Lfa-1 mediates a variety of heterotypic and homotypic intercellular adhesions through interaction with icam-1 (cd54) and icam-2 (cd102), including participation in the immunological synapses between cd8+ t lymphocytes and antigen-presenting cells. Mab m17/4 blocks a variety of lfa-1-mediated cells interactions in vitro, and costimulatory effects have also been described. In vivo treatment with m17/4 mab reduces the severity of graft-versus-host reactions, prolongs allograft survival, inhibits the development of autoimmunity, and blocks substance p-induced leukocyte migration. The m17/4 and 2d7 (cat. No. 553120) Antibodies are reported to recognize different epitopes of the cd11a molecule.