Cd11b Rat Anti-Mouse, Percp-Cy5.5, Clone: M1/70, Bd, Rat Monoclonal Antibody, Each

Details:

The m1/70 monoclonal antibody specifically binds to cd11b, also known as integrin alpha m (itgam or α;m) . Cd11b is a 170-kda type 1 transmembrane glycoprotein and belongs to the integrin alpha chain family. Cd11b serves as the alpha chain of the heterodimeric mac-1 integrin (cd11b/cd18, α;mβ;2), also known as complement receptor 3 (cr3) . Mac-1 mediates adhesion to icam-1 (cd54), icam-2 (cd102), fibrinogen and binding to c3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and b-1 b lymphocytes. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that cd62l (l-selectin) is shed from the cell surface. The m1/70 antibody reportedly blocks cell adherence and c3bi binding but does not block cell-mediated lysis. Cross-reaction of the m1/70 antibody with cd11b expressed on human monocytes, polymorphonuclear leukocytes, and nk cells has been reported.