Cd120a Mouse Anti-Human, Biotin, Clone: Mabtnfr1-B1, Bd, Mouse Monoclonal Antibody, Each

Details:

The tnfr1-b1 antibody reacts with the extracellular domain of cd120a which is also known as the 55 kda receptor for the human cytokines, tumor necrosis factor (tnf) and lymphotoxin-alpha (lt- α; ). This receptor is referred to as the p55 or type i tumor necrosis factor receptor (tnfri). Tnfri are expressed by a variety of cell lines, tumor cells, and normal cell types including t cells, monocytes, macrophages, neutrophils, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Naive b cells express very low or undetectable levels of tnfri whereas mature erythrocytes and platelets are uniformly negative for tnfri expression. For the generation of the mabtnfr1-b1 hybridoma, balb/c mice were immunized with purified, full-length human tnfri protein that was expressed by insect cells that were infected with a recombinant human tnfri-baculovirus expression vector. Mabtnfr1-b1 specifically binds to natural and recombinant truncated forms of tnfri.