Cd138 Mouse Anti-Human, Fitc, Clone: Mi15, Bd, Mouse Monoclonal Antibody, Each

Details:

Reacts with cd138 (syndecan-1), an 85-92kda single chain transmembrane protein, strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. It is also expressed on pre-b cells, immature b cells, and plasma cells, but not on mature circulating b-lymphocytes. Syndecan-1 is a member of the family of transmemrane heparan sulfate proteoglycans. It is also expressed on some non-hematopoietic cells, including embryonic mesenchymal cells, vascular smooth muscle cells, endothelial and neural cells. Cd138 binds to many extracellular matrix proteins through its heparan sulfate side-chains, like fibronectin, collagen types i, iii, and v, tenascin, thrombospondin, and antithrombin iii. It is considered an extracellular matrix receptor that may serve as a co-receptor for fibroblast growth factor and related molecules. Monoclonal antibody mi15 blocks the binding of clone b-b4 but not clone dl-101 (other anti-syndecan-1 antibodies) by flow cytometric analysis. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at bd biosciences pharmingen during antibody development only or reported in the literature.Host species: mouseclone: mi15isotype: igg1 κspecies reactivity: humanflow cytometry