Cd19 Rat Anti-Mouse, Unlabeled, Clone: 1d3, Bd, Rat Monoclonal Antibody, Each

Details:

The 1d3 antibody reacts with cd19, a b lymphocyte-lineage differentiation antigen. Cd19, a 95kda transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout b-lymphocyte development from the pro-b cell through the mature b-cell stages. Terminally differentiated plasma cells do not express cd19. On the surface of mature b cells, the cd19 molecule associates with cd21 (cr-2) and cd81 (tapa-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with cd19-deficient mice have suggested that the level of cd19 expression affects the generation and maturation of b cells in the bone marrow and periphery. B-1 lineage b cells, also known as cd5+ b cells, are drastically reduced or absent in cd19-deficient mice.Increased levels of cd19 expression correlate with increased frequencies of peritonal and splenic b-1 cells and reduced numbers of conventional b lymphocytes in the periphery. Cd19 participates in b-lymphocyte development, b-cell activation, maturation of memory b cells and regulation of tolerance. Cd19 has also been detected on peritoneal mast cells, co-localized with cd21/cd35, and it is proposed to play a role in complement-mediated mast-cell activation. This antibody is routinely tested by immunohistochemistry. Other applications were tested at bd biosciences pharmingen during antibody development only or reported in the literature.