Cd209 Mouse Anti-Human, Unlabeled, Clone: Dcn46, Bd, Mouse Monoclonal Antibody, Each

Details:

The dcn46 antibody specifically binds to dendritic cell-specific icam-3 grabbing nonintegrin (dc-sign or cd209), a type-ii membrane protein of approximately 44 kda with a mannose-binding c-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence is identical to the hiv-1 envelope gp120-binding c-type lectin, and reports suggest that dc-sign binds to hiv-1 gp120 and effectively transmits infectious hiv-1 to resting t lymphocytes expressing cd4 and chemokine receptors. The c-type lectin domain of dc-sign is also capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that dc-sign enables the highly efficient migration of dendritic cells from blood into the tissues. It can interact with icam-2, which has a similar sequence as icam-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, dc-sign mediates dendritic cells rolling and transendothelial migration, and its interaction with icam-2 is essential to specific migratory functions of dendritic cells.