Cd247 With Control Mouse Anti-Human, Unlabeled, Clone: 8d3, Bd, Mouse Monoclonal Antibody, Each

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The t-cell receptor (tcr), expressed by thymus-derived lymphocytes, is a multi-component complex responsible for recognizing antigen in the context of mhc molecules. Ti is the antigen-specific binding component of the tcr. On the majority of peripheral t lymphocytes ti is present as a disulfide-linked α - β heterodimer. A minor fraction express ti as a γ- δ heterodimer. The ti subunits are ig-like, each containing v and c regions. Ti is noncovalently associated with an invariant set of molecules referred to as the cd3 subunits. Cd3 appears early in thymocyte differentiation and remains expressed on all mature t lymphocytes. In the mouse, it consists of five chains, γ(gamma), δ (delta), ε (epsilon), ζ (zeta), and p21. The relative masses of the mouse cd3 chains are 21, 28, 26, 32 (dimer), and 21 kda respectively. The 8d3 antibody recognizes the ζ chain of the human and mouse t cell antigen receptor-associated cd3 complex. It reacts with 16 kda unphosphorylated monomers and 32 kda unphosphorylated dimers. It does not appear to recognize 21 kda phosphorylated monomers or 42 kda phosphorylated dimers. A synthetic peptide corresponding to a region of human cd3 ζ was used as immunogen.