Cd253 Mouse Anti-Human, Na/Le, Unlabeled, Clone: Rik-2, Bd, Mouse Monoclonal Antibody, Each

Details:

The rik-2 monoclonal antibody specifically binds to cd253 which is also known as trail (tnf-related apoptosis-inducing ligand) and apo2 ligand (apo-2l). Cd253 is a member of the tumor necrosis factor superfamily and is encoded by the tnfsf10 gene. Cd253 is a type ii membrane protein that may be expressed as a full-length, cell surface associated protein as well as in a soluble form. Both surface and soluble forms of trail rapidly induce apoptosis by a wide range of cell lines but not by normal cells. Trail is expressed by activated t cells, nk cells, dendritic cells, monocytes and by a variety of non-lymphoid cells. Trail can bind to and exert apoptosis through dr4 (trail-r1) and dr5 (trail-r2) receptors. It can also bind to decoy receptors, including dcr1/trid/trail-r3 and dcr2/trundd/trail-r4, and possibly opg/tnfrsf11b, which may serve to regulate trail activity. Trail has been shown to be involved in t cell-mediated cytotoxicity, however its mechanism of action remains to be fully elucidated. The rik-2 clone was selected based on its ability to block trail-mediated cytotoxic activity.