Cd28 Mouse Anti-Human, Unlabeled, Clone: L293, Bd, Mouse Monoclonal Antibody, Each

Details:

The cd28 antibody, clone l293, is derived from hybridization of sp2/0-ag14 mouse myeloma cells with spleen cells from balb/c mice immunized with the hpb-all t-cell line. The cd28 antigen, a disulfide-linked homodimeric glycoprotein, mr 44 kilodaltons (kd), is a cell-adhesion molecule (cam) and functions as the ligand for cd80 (b7-1) and cd86 (b7-2) antigens, which are present on activated b lymphocytes, monocytes, and dendritic cells. Interaction of the cd28 antigen with cd80 or cd86 antigens, or both, co-stimulates cd2 and cd3 antigen/t-cell antigen receptor (tcr)–dependent t-cell–mediated proliferation and cytotoxicity.