CD39 Mouse anti-Human, PerCP-Cy5.5, Clone: TU66, BD, Mouse Monoclonal Antibody, Each

Details

The TU66 monoclonal antibody reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) an ectoenzyme that degrades ATP to AMP. It is a member of the family of ectonucleoside triphosphate dihydrolases (E-NTPDases) known to be involved in regulation of extracellular nucleotide catabolism, controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is expressed on a subset of T cells, B cells and dendritic cells with weak staining of monocytes and granulocytes. Recently, CD39 has been found to be expressed primarly by immune-suppressive Foxp3( ) regulatory T (Treg) cells in both human and mice. In humans, CD39 is restricted to a subset of Foxp3 regulatory effector/memory-like T cells. In mice, the enzyme is present on most if not all CD4 CD25 cells and CD39 expression is driven by Foxp3. It is thought that CD39 allows Treg cells to enter inflamed areas where high levels of ATP are present.