CD40 Mouse anti-Human, NA/LE, Unlabeled, Clone: 5C3, BD, Mouse Monoclonal Antibody, Each

Details

This antibody reacts with a 45-48kDa type I integral membrane glycoprotein present on peripheral blood and tonsillar B cells, but not expressed on terminally differentiated B cells. CD40 is also present on some epithelial cells, carcinomas and lymphoid dendritic cells. This antibody is useful for studies of B-cell growth and function. Anti-CD40 antibodies have been reported to stimulated B-cell proliferation when costimulated with anti-?, anti-CD20 antibodies or with phorbol esters. 5C3 is capable of inducing B-cell proliferation when presented with IL-4. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only.