Cd40 Rat Anti-Mouse, Unlabeled, Clone: 3/23, Bd, Rat Monoclonal Antibody, Each

Details:

The 3/23 clone reacts with cd40, a 40-50kda glycoprotein expressed on b lymphocytes and other antigen-presenting cells. Cd40 has been reported to be transiently expressed on activated cd4+ and cd8+ t cells and in some mouse strains, the 3/23 mab has been reported to react with 5-10% of t lymphocytes in adult mouse, but not neonatal, spleen. Cd40 plays a key role in b-cell growth and differentiation where interactions of cd40 with its ligand, cd154, are involved in the initiation, effector, and memory stages of cell-mediated immune responses. In addition, cd40 has been reported to be involved with the triggering of nk cells and nk-t cells. Ligation of cd40 with the 3/23 antibody has been reported to induce splenic b cells to express the costimulatory molecule cd86 (b7-2). In addition, although the 3/23 antibody by itself is a weak b-cell mitogen, it has been reported to synergize markedly with mitogenic anti-igm, anti-igd mab or il-4 to promote b-cell proliferation.