Cd43 Rat Anti-Mouse, Unlabeled, Clone: S7, Bd, Rat Monoclonal Antibody, Each

Details:

The s7 monoclonal antibody specifically binds to the 115 kda glycosylated form of cd43 (ly-48, leukosialin). Cd43 is expressed on il-7-responsive pro-b cells, plasma cells, peritoneal and splenic cd5+ b cells (b-1 cells), granulocytes, monocytes, macrophages, platelets, natural killer cells, thymocytes, peripheral t cytotoxic/suppressor cells, and most t helper cells, but not resting conventional peripheral b cells. Cd43 expression has also been detected on pluripotent hematopoietic stem cells and myeloid, lymphoid, and nk-cell progenitors in the bone marrow. Studies of cd43-deficient mice indicate that cd43 participates in the negative regulation of t-cell activation and adhesion.