Cd45ro Mouse Anti-Human, Apc, Clone: Uchl1, Bd, Mouse Monoclonal Antibody, Each

Details:

Cd45ro, a member of the cd45 family that includes cd45, cd45ra, and cd45rb, recognizes a 180-kilodalton (kd) isoform of the leucocyte common antigen (lca). The cd45 antigen is a protein tyrosine phosphatase. In peripheral blood, the cd45ro antigen is present on approximately 40% of resting peripheral blood t lymphocytes, including the cd4+ and cd8+ subpopulations, as well as on most thymocytes and activated t lymphocytes. It is also expressed on monocytes, macrophages, and granulocytes. The cd45ro antigen is present at low density early in the t-lymphocyte maturation cycle. Upon activation by phytohemagglutinin (pha) or alloantigen, naive t lymphocytes first acquire cd45ro and then lose cd45ra. When these activated t lymphocytes are rechallenged, the cells that exhibit a secondary response are primarily cd45ro+ , leading to the concept that cd45ro+ cells are a primed population of memory t lymphocytes.