Cd5 Rat Anti-Mouse, Fitc, Clone: 53-7.3, Bd, Rat Monoclonal Antibody, Each

Details:

The 53-7.3 Clone has been reported to react with a monomorphic epitope of cd5, a member of the scavenger receptor cysteine-rich protein superfamily and the major ligand of cd72, found on thymocytes, t lymphocytes, thymic nk-t cells, and a subset of b lymphocytes, but not on nk cells or splenic nk-t cells. The level of surface cd5 expression is developmentally regulated in the thymus, starting with low levels on cd4-cd8- thymocytes and increasing as they mature to cd4+cd8+ then cd4+cd8- or cd4-cd8+ thymocytes. Relatively high levels are maintained on peripheral t lymphocytes. The level of cd5 antigen detected on t helper cells has been reported to be somewhat higher than that on t cytotoxic/suppressor and b cells. Few, if any, intestinal intraepithelial lymphocytes bearing the γδ t-cell receptor express cd5. Phenotypic, anatomical, functional, developmental, and pathogenic characteristics of peripheral cd5+ b cells suggest that they may represent a distinct lineage, known as b-1 cells. The frequency of these cd5+ b cells has been reported to show strain-dependent variation. An additional population of cd5+ b lymphocytes resides in the thymus, where it matures from intrathymic b-cell progenitors. It has been proposed that cd5 is a costimulatory molecule which mediates interactions of cells in the immune system and negatively regulates signal transduction mediated by the t-cell receptor and b-cell receptor. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at bd biosciences pharmingen during antibody development only or reported in the literature.Host species: ratclone: 53-7.3Isotype: igg2a κspecies reactivity: mouseimmunogen: mouse thymus / spleenflow cytometry