Cd54 Hamster Anti-Mouse, Unlabeled, Clone: 3e2, Bd, Hamster Monoclonal Antibody, Each

Details:

The 3e2 antibody reacts with cd54 (icam-1), a 95kda member of the ig superfamily found on lymphocytes, vascular endothelium, high endothelial venules, epithelial cells, macrophages, and dendritic cells. Icam-1 is a ligand for lfa1 (cd11a/cd18) and mac-1 (cd11b/cd18). Its expression is upregulated upon stimulation by inflammatory mediators such as cytokines and lps. Studies with mouse icam1-transfected antigen-presenting cells, with cd54-blocking antibodies, and in cd54-deficient mice indicate that cd54 participates in inflammatory reactions and antigen-specific immune responses. In addition, there is evidence that cd54 is a receptor involved in mhc-non-restricted responses to weakly immunogenic tumor cells. The 3e2 antibody has been reported to block in vitro and in vivo intracellular adhesion events involved in immune responses.