Calbiochem 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 μM)., Each

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A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6μM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest.