Calbiochem InSolution HIF-1 Inhibitor, A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50, Each

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A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6μM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.