Calbiochem Insolution Hif-1 Inhibitor, A Cell-Permeable Amidophenolic Compound That Inhibits Hypoxia-Induced Hif-1 Transcription Activity (Ic50, Each

Details:

A cell-permeable amidophenolic compound that inhibits hypoxia-induced hif-1 transcription activity (ic50 = 0.7 And 2.6μM using ags and hep3b cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular hif-1α protein, while exhibiting no apparent effect on the cellular level of hif-1α mrna or that of hif-1β protein.