Calbiochem™ Itk Inhibitor, Bms-509744, Each

Details:

A cell-permeable aminothioaryl-thiazolo compound that potently inhibits itk kinase activity (ic50 = 19nm; [atp] = 1μm) in an atp-competitive manner by stabilizing itk activation loop in a substrate-blocking, inactive conformation, inhibiting fyn, ir, lck, btk only at much higher concentrations (ic50