Calbiochem Pkr Inhibitor Iii, 7dg Cas 26927-01-5, A Cell-Permeable Gedunin Analog, Each

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A cell-permeable gedunin analog that directly targets pkr via reversible interaction inhibits pkr-mediated cellular events by disrupting pkr signaling complexes assembly, such as iκk complex and inflammasome/pyroptosome, resulting in effective blockage of lps-induced iκbβ degradaion (20μm) and protection against anthrax toxin lt-induced caspase-1 activation as well as subsequent pyroptosis (10μm) in murine macrophage j774 cultures. Pkr is also known to mediate lt-induced apoptosis via its kinase activity in lps-primed macrophages derived from c57bl/6 with a resistent nlrp1 allele, inhibitable by c16 (cat. Nos. 527450 And 527451), but not by 7dg, while lt-induced pyroptosis in j774 cultures is insensitive to c16 treatment.