Calbiochem Pp1 Analog V, 2,3-Dmb-Pp1, A Cell-Permeable 3-Mb-Pp1 Analog That Is More Effective Than 3-Mb-Pp1 In Inhibiting Syk, Each

Details:

A cell-permeable 3-mb-pp1 (cat. No. 529582) Analog that is more effective than 3-mb-pp1 in inhibiting sykm442a s505a aska- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% Inhibition, respectively, by 1μm 2,3-dmb-pp1 or 3-mb-pp1) in syk masa-expressing dt40 cells. Also shown to selectively inhibit l159g aska, but not wt, pdk1-dependent gsk3andalpha ser21 and s6 ser235/236 phosphorylation upon igf1 stimulation in mes cells.