Il-1Β Mouse Anti-Human, Unlabeled, Clone: As10, Bd, Mouse Monoclonal Antibody, Each

Details:

The as10 antibody reacts with human interleukin-1β (il-1β) which is also known as endogenous pyrogen (ep), leukocyte endogenous mediator (lem), mononuclear cell factor (mcf) and lymphocyte-activating factor (laf). Il-1β is a proinflammatory cytokine that is synthesized as a precursor of 31kda and is converted intracellularly to the mature 17.5Kda form, after cleavage by the il-1β-converting enzyme (ice). In healthy individuals, il-1β is secreted non-constitutively by blood monocytes, tissue macrophages and dendritic cells. Il-1β is also constitutively expressed in the human hypothalamus. Many malignant tumors express il-1β as part of their neoplastic nature. The immunogen used to generate the as10 hybridoma was recombinant human e. Coli-expressed recombinant il-1β. The as10 antibody does not cross react with mouse il-1β. This is a neutralizing antibody.