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This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology. Intact IgG appears on a non-reducing gel as ∽150 kDa band and upon reduction generating a ∽25 kDa light chain band and a ∽50 kDa heavy chain. Recombit rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.JAM-A is a tight junction-associated protein that is a member of the immunoglobulin (Ig) superfamily. JAM-A is expressed on endothelial and epithelial cells, and its sub-cellular distribution is modulated by inflammatory cytokines. It is also expressed on circulating leukocytes and platelets, and lymphoid tissues. It is expressed on various tissues and cells at tight junctions, where it co-localizes with the tight junction proteins Occludin, ZO-1, and Cingulin.
