NK1 receptor antagonist used to treat nausea. It inhibits binding of substance P and prevents substance P’s proliferative and pro-angiogenic signaling cascade. It also may decrease depression-like behaviors, Each

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Aprepitant is an inhibitor of the tachykinin/neurokinin 1 (NK1) receptor that acts as an antiemetic or anti-nausea medicine. Aprepitant also exhibits some anticancer chemotherapeutic and anti-angiogenic benefit through its inhibition of NK1 receptors, preventing binding of substance P and inhibiting substance P’s proliferative and pro-angiogenic signaling cascade. This compound may also display some antidepressant activity, although in vivo and clinical results have been mixed.