PDE4 inhibitor used to treat psoriasis and psoriatic arthritis. It also decreases levels of iNOS, IL-23, and TNF-a, Each

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Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) that is clinically used to treat psoriasis and psoriatic arthritis. Apremilast exhibits anti-inflammatory and immunomodulatory activities, increasing levels of cAMP and IL-10 and decreasing levels of iNOS, IL-23, and TNF-a in vitro and in vivo.