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Specifications Synonyms: alpha-Toluenesulfonyl fluoride; Benzylsulfonyl fluoride; PMSF; Phenylmethylsulfonyl fluorideCAS Number: 329-98-6Formula: C7H7FO2SFormula Weight: 174.19Linear Formula: C7H7FO2SMDL No.: MFCD00007424Purity: >=98.5% (GC)Beilstein Registry Number: 2088311EC Number: 206-350-2UNSPSC Code: 12352202Application: Inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase. Not as effective or as toxic as DFP. Effective concentration 0.1-1 mM. Half-life = 1 hr. at pH 7.5.Application: Phenylmethanesulfonyl fluoride has been used in following applications:. cell fractionation.. used as a supplement in nuclear protein extraction.. inhibitor of cholesterol esterase (CE) and pseudocholinesterase (PCE).. used for the collection of blood prior to centrifugation to quantify plasma ANP levels.Biochem/physiol Actions: Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.RTECS: XT8040000RIDADR: UN 2928 8(6.1) / PGIIWGK Germany: 3R Codes: 25-34S Codes: 26-36/37/39-45IOD Codes: TSymbol: GHS05, GHS06Signal Word: DangerHazard Statements: H301-H314Precautionary statements: P280-P301 P310 P330-P303 P361 P353-P304 P340 P310-P305 P351 P338
