[Pro3]-Gip (Mouse), Gip Receptor Antagonist, Each

Details:

[Pro3]-gip (mouse) is a gip receptor antagonist (ic50 = 2.6μM). Inhibits gip-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of gip on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insulin sensitivity, and glucose response to feeding in ob/ob mice.