Spexin, Potent Gal2/3 Agonist; Exhibits Anxiolytic Effects In Vivo, Each

Details

Spexin is a potent galanin receptor 2/3 (gal2/gal3) agonist (ec50 values are 45.7 And 112.2 Nm, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates lh secretion in goldfish. Exhibits anxiolytic effects in vivo.