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Specifications Synonym: SOD, Superoxide: superoxide oxidoreductaseCAS Number: 9054-89-1EC Number: 232-943-0Enzyme Commission (EC) Number: 1.15.1.1MDL Number: MFCD00132404Biochem/physiol Actions Catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. Plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO.3 SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.4,5General 'Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.Unit Definition One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 ml reaction volume. Xanthine oxidase concentration should produce an initial ?A550 of 0.025 ± 0.005 per min.Physical form Lyophilized powder containing potassium phosphate buffer saltsBiochem/physiol Actions Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids.1,2 It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines.3 It is also known to be a biological source of reactive oxygen species.4Application Superoxide dismutase from bovine erythrocytes has been used in a study to assess a kinetic model of radiation-induced inactivation of superoxide dismutase in nitrous oxide-saturated solutions. 1 Superoxide dismutase from bovine erythrocytes has also been used in a study to investigate the possible participation of superoxide anion in the intestinal tryptophan 2,3-dioxygenase reaction. 2Form: lyophilized powderComposition: Protein, =95% biuretPl: 4.95Storage Temp.: -20°CGene Information: cow ... SOD1(281495), SOD2(281496)
