Tat-Cyclo-Cllfvy, Selective Hif-1 Dimerization Inhibitor, Each

Details

Tat-cyclo-cllfvy is a selective hif-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant hif-1α, but not hif-2α, with hif-1β (ic50 = 1.3 μM) . Inhibits hypoxia-induced hif-1 activity, and decreases vegf and caix expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic huvecs.