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c-kit is a transmembrane receptor tyrosine kinase. It binds to stem cell factor (SCF). It is expressed in many tissues and cells. C-kit/SCf is involved in development of several lineages of stem cells, such as germ cells, neural crest-derived melanocytes and hematopoietic precursor cells. Ab-3 does not interfere with the binding of SCF to c-kit Host Species: MouseClone: K45Isotype: IgG2aSpecies Reactivity: Human. Others not known.Epitope: Extracellular second N-terminus Ig-like domain of c-kitImmunogen: Recombinant human extracellular c-kit fragmentMolecular Weight: 145kDaPositive Control: Skin, GI Stromal Tumor (GIST)Cellular Localization: Membrane/cytoplasmicRecommended for:Immunohistochemistry (Frozen or fixed in methacarn or Stieve's and embedded in paraffin)Immunofluorescence Note:USA: RUO; Int'l: RUO
