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53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.Host Species: MouseClone: DO-7Isotype: IgG2b/κSpecies Reactivity: Human, Monkey, Cow. Others not known.Epitope: aa 37-45Immunogen: Recombinant human wild-type p53 protein expressed in E. coliMolecular Weight: 53kDaPositive Control: SKBR-3 or MDA-231 cells, Colon CACellular Localization: Nuclear Recommended for:Immunohistochemistry (Formalin/paraffin)Western BlottingImmunofluorescenceImmunoprecipitation (Denatured verified)Flow Cytometry
