53 Ab-6 Mouse Monoclonal Antibody, Achieve accurate, reproducible results with the  p53 Ab-6, Mouse Monoclonal Antibody, Each

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53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. Host Species: MouseClone: DO-1Isotype: IgG2aSpecies Reactivity: Human, Monkey and Cow. Reacts weakly with Mouse and Rat. Others not known.Epitope: aa 11-25Immunogen: Recombinant human wild-type p53 protein expressed in E. coliMolecular Weight: 53kDaPositive Control: SKBR-3 cells or MDA-231 cells, Colon CACellular Localization: Nuclear Recommended for:Immunohistochemistry (Formalin/paraffin)Western BlottingImmunofluorescenceImmunoprecipitation (Native and denatured)Flow CytometryGel Supershift Assay Note:USA: RUO; Int'l: RUO