Bibo 3304 Trifluoroacetate, Highly Selective Npy Y1 Receptor Antagonist, Each

Details:

Bibo 3304 trifluoroacetate is a high affinity npy y1 receptor antagonist (ic50 values are 0.38 And 0.72 Nm at human and rat receptors respectively) that displays > 2600-fold selectivity over y2, y4 and y5 receptors. Inhibits npy- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of npy.