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Cariporide, Selective NHE1 inhibitor; cardioprotective and antitumor, Each

247.08

Details

Cariporide is a selective Na /H exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.

Additional Information

SKU 10542396
UOM Each
UNSPSC 41116105
Manufacturer Part Number 5358/10