(D(Ch2)51,Tyr(Me)2,Arg8)-Vasopressin, Selective Vasopressin V1a Antagonist, Each

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(D(ch2)51,tyr(me)2,arg8)-vasopressin is a selective vasopressin v1a receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (ic50 values are 5 and 30 nm respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.